我想出了这个答案。调用此方法并传递唯一的ID
  
      public static void PreventMultipleInstance(string applicationId)
    {
        // Under Windows this is:
        //      C:\Users\SomeUser\AppData\Local\Temp\ 
        // Linux this is:
        //      /tmp/
        var temporaryDirectory = Path.GetTempPath();
        // Application ID (Make sure this guid is different accross your different applications!
        var applicationGuid = applicationId + ".process-lock";
        // file that will serve as our lock
        var fileFulePath = Path.Combine(temporaryDirectory, applicationGuid);
        try
        {
            // Prevents other processes from reading from or writing to this file
            var _InstanceLock = new FileStream(fileFulePath, FileMode.OpenOrCreate, FileAccess.ReadWrite, FileShare.None);
            _InstanceLock.Lock(0, 0);
            MonoApp.Logger.LogToDisk(LogType.Notification, "04ZH-EQP0", "Aquired Lock", fileFulePath);
            // todo investigate why we need a reference to file stream. Without this GC releases the lock!
            System.Timers.Timer t = new System.Timers.Timer()
            {
                Interval = 500000,
                Enabled = true,
            };
            t.Elapsed += (a, b) =>
            {
                try
                {
                    _InstanceLock.Lock(0, 0);
                }
                catch
                {
                    MonoApp.Logger.Log(LogType.Error, "AOI7-QMCT", "Unable to lock file");
                }
            };
            t.Start();
        }
        catch
        {
            // Terminate application because another instance with this ID is running
            Environment.Exit(102534); 
        }
    }